Clomocycline is a tetracycline-class antibacterial active pharmaceutical ingredient. It is also known by the synonym chlormethylenecycline and is identified by CAS Number 1181-54-0. Clomocycline has the molecular formula C23H25ClN2O9 and molecular weight 508.91 g/mol.
Clomocycline is a chlorinated tetracycline antibiotic associated with inhibition of bacterial protein synthesis. It has been used for the treatment of bacterial infections and is classified within the tetracycline antibacterial group.
The substance is listed by FDA's Global Substance Registration System with UNII YP0241BU76, while the corresponding sodium salt is separately identified as Clomocycline Sodium.
Clomocycline is an antibacterial agent belonging to the tetracycline class. Historical clinical references associate its use with bacterial infections, including dermatological bacterial conditions.
Clomocycline should be evaluated against the current approved product/API specification and applicable regulatory requirements. Identity should be confirmed using appropriate analytical methods such as chromatographic and spectroscopic testing.
Store in a tightly closed container and protect from unsuitable environmental conditions, light and moisture according to the approved product specification and safety documentation.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.1% |
| Residue on Ignition | NMT 0.2% |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |