Clofoctol is a synthetic antibacterial active pharmaceutical ingredient belonging to the phenol-derived antimicrobial class. It has been used as a local antibacterial agent, particularly in pharmaceutical preparations intended for the treatment of infections of the respiratory tract.
Clofoctol is chemically identified as 2,2'-Methylenebis(4-chlorophenol). It has the molecular formula C₁₃H₁₀Cl₂O₂, molecular weight 269.12 g/mol, and CAS number 37693-01-9.
Clofoctol has demonstrated antibacterial activity against susceptible Gram-positive microorganisms. Its antimicrobial activity is associated with disruption of bacterial cellular functions and membrane integrity.
Clofoctol has historically been used in pharmaceutical preparations for localized treatment of bacterial infections, particularly infections involving the respiratory tract.
Its pharmaceutical applications have included:
The actual indication depends on the finished dosage form, strength, route of administration and applicable regulatory approval.
Clofoctol is a phenolic antibacterial compound. Its antimicrobial activity is primarily associated with interaction with bacterial cell membranes and interference with essential cellular processes.
The compound can affect bacterial membrane function, resulting in disruption of cellular integrity and inhibition of bacterial growth.
Its pharmacological properties include:
Clofoctol is a chlorinated bisphenolic compound containing two phenolic hydroxyl groups.
Product Name: Clofoctol
Chemical Name: 2,2'-Methylenebis(4-chlorophenol)
CAS Number: 37693-01-9
Molecular Formula: C₁₃H₁₀Cl₂O₂
Molecular Weight: 269.12 g/mol
Chemical Class: Chlorinated phenol
Pharmacological Class: Antibacterial
Physical Form: Solid
Appearance: White to almost-white crystalline powder
Water Solubility: Practically insoluble in water
Clofoctol API can be used as an active ingredient in pharmaceutical development and manufacturing of antibacterial formulations.
Its physicochemical characteristics make appropriate control of particle properties, purity, related substances and formulation compatibility important during pharmaceutical development.
Quality evaluation may include:
Each commercial batch should be released against the manufacturer's approved specification and supported by a batch-specific Certificate of Analysis.
For pharmaceutical customers, Clofoctol API can be supported with appropriate technical and quality documentation, depending on the supplied grade and regulatory requirements.
Typical documentation may include:
Clofoctol should be handled and stored according to the applicable API specification.
Recommended handling considerations include:
Consistent API quality is important for reproducible pharmaceutical manufacturing. Clofoctol intended for pharmaceutical applications should therefore undergo appropriate identity, purity and assay testing.
Important quality characteristics include:
Chemical identity: Confirms the API is Clofoctol.
Assay purity: Ensures consistent active-ingredient content.
Related substances: Controls chemically related impurities.
Physical characteristics: Supports consistent formulation processing.
Documentation: Provides traceability and quality assurance.
Clofoctol is a specialized antibacterial active pharmaceutical ingredient used in pharmaceutical applications. Pharmaceutical-grade material can be supplied to formulation manufacturers and pharmaceutical companies requiring Clofoctol for product development or commercial manufacturing.
For Clofoctol API specifications, CoA, technical documentation, packaging options and commercial supply information, customers can contact the supplier for product-specific details.
| Parameter | Specification |
|---|---|
| Identification | IR absorption conforms to Clofoctol reference standard |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 1.0% |
| Water Content | NMT 1.0% |