Clodronic Acid, also known as Clodronate, is a first-generation bisphosphonate active pharmaceutical ingredient belonging to the class of non-nitrogen-containing bisphosphonates. It is chemically characterized by a dichloromethylene group attached to two phosphonic acid groups.
Clodronic Acid has the molecular formula CH₄Cl₂O₆P₂, molecular weight 244.89 g/mol, and CAS number 10596-23-3. It is an achiral compound with no defined stereocenters or optical activity.
Clodronic Acid and its pharmaceutical salts are associated with inhibition of bone resorption and reduction of abnormal calcium release from bone. Clodronate pharmaceutical preparations have been used in the management of conditions involving increased bone resorption, including hypercalcaemia associated with malignancy and osteolytic bone disease.
The API is particularly relevant to pharmaceutical formulations containing clodronate, with disodium clodronate being an important pharmaceutical salt form.
Clodronate belongs to the bisphosphonate class. Bisphosphonates have a strong affinity for bone mineral and become associated with areas of active bone remodeling.
After uptake by bone-resorbing cells, clodronate can interfere with cellular energy metabolism and promote osteoclast dysfunction and apoptosis. This contributes to suppression of excessive bone resorption.
Its pharmacological activity is therefore associated with:
Clodronic Acid is a highly polar phosphonic-acid-containing compound. The parent compound is chemically represented as (Dichloromethylene)diphosphonic acid.
Product Name: Clodronic Acid
Synonyms: Clodronate; Dichloromethylene diphosphonic acid
CAS Number: 10596-23-3
Molecular Formula: CH₄Cl₂O₆P₂
Molecular Weight: 244.89 g/mol
IUPAC Name: [Dichloro(phosphono)methyl]phosphonic acid
Physical State: Solid
Stereochemistry: Achiral
Optical Activity: None
PubChem confirms the molecular formula, CAS number, molecular weight and achiral nature of the parent compound.
For your website, this distinction is important.
Clodronic Acid:
CAS 10596-23-3
Formula CH₄Cl₂O₆P₂
Molecular Weight 244.89 g/mol
Clodronate Disodium:
CAS 22560-50-5
Formula CH₂Cl₂Na₂O₆P₂
Molecular Weight 288.85 g/mol
Clodronate Disodium Tetrahydrate:
Formula CH₁₀Cl₂Na₂O₁₀P₂
Molecular Weight 360.91 g/mol.
Therefore, if your company's actual product is Clodronate Disodium, do not use the parent-acid molecular weight of 244.89 g/mol on the product page.
| Parameter | Specification |
|---|---|
| Identification | Conforms by validated identity testing |
| Assay (HPLC) | ≥ 98.0% |
| Loss on Drying | NMT 0.1% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 1.0 – 3.0 |
| Water Content | ≤ 1.0% |