Clobetasone Butyrate is a synthetic topical glucocorticoid and active pharmaceutical ingredient used in dermatological formulations. It is classified as a corticosteroid and is used in topical preparations such as creams and ointments.
Clobetasone Butyrate has the molecular formula C₂₆H₃₂ClFO₅, molecular weight 478.98 g/mol, and CAS No. 25122-57-0.
The BP identifies clobetasone butyrate as a glucocorticoid and specifies protection from light.
| Field | Value |
|---|---|
| Product Name | Clobetasone Butyrate |
| CAS Number | 25122-57-0 |
| Alternate CAS / CAS 2 | None |
| Grade | API / Pharmaceutical Grade |
| Category | Active Pharmaceutical Ingredient |
| Appearance | White or almost-white crystalline powder |
| Molecular Formula | C₂₆H₃₂ClFO₅ |
| Molecular Weight | 478.98 g/mol |
| Chemical Class | Synthetic corticosteroid |
| Therapeutic Class | Glucocorticoid |
| Pharmacological Class | Topical corticosteroid |
| Physical Form | Crystalline solid |
| Water Solubility | Practically insoluble |
| Storage | Protected from light |
| Standards | BP |
The BPCRS listing confirms CAS 25122-57-0, formula C₂₆H₃₂ClFO₅, molecular weight 478.98, and pharmaceutical primary-standard status.
21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate.
| Parameter | Specification |
|---|---|
| Identification | IR absorption conforms to Clobetasone Butyrate reference; HPLC retention time corresponds to reference standard |
| Assay (HPLC) | 99.0% – 101.0% |
| Loss on Drying | NMT 0.5% |
| Individual Impurity | NMT 0.10% |
| Total Impurities | NMT 0.50% |
| Melting Point | Approximately 223°C – 230°C |