Clazosentan API

Clazosentan is a selective endothelin A (ETA) receptor antagonist developed for pharmaceutical applications involving endothelin-mediated vasoconstriction. Clazosentan is associated with prevention of cerebral vasospasm and vasospasm-related complications following aneurysmal subarachnoid hemorrhage.

Clazosentan has the molecular formula C25H23N9O6S and molecular weight 577.57 g/mol. The free acid is identified by CAS No. 180384-56-9.

The clazosentan disodium salt is identified by CAS No. 503271-02-1, molecular formula C25H21N9Na2O6S, and molecular weight approximately 621.54 g/mol.

Product Highlights

Generic Name: Clazosentan
CAS No.: 180384-56-9
Disodium Salt CAS No.: 503271-02-1
Molecular Formula: C25H23N9O6S
Molecular Weight: 577.57 g/mol
Salt Form: Clazosentan Disodium Salt
Therapeutic Class: Endothelin Receptor Antagonist
Target: Endothelin A (ETA) receptor
Physical Form: Solid / crystalline powder
Appearance: Off-white to light-yellow solid/powder
Storage: Store in a cool, dry and well-closed container; protect from moisture and light as appropriate.

Publicly disclosed manufacturing information describes clazosentan disodium salt as a white to pale-yellow crystalline powder.

Detailed Specifications

Parameter	Specification
Identification	Conforms by HPLC and reference standard
Assay (HPLC)	NLT 99.0%
Loss on Drying	NMT 0.1%
Residue on Ignition	NMT 0.5%
pH (1% Solution)	5.0 – 8.0

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