Cisapride is a synthetic benzamide derivative and gastroprokinetic active pharmaceutical ingredient. It acts primarily by enhancing gastrointestinal motility through activity involving the serotonin system, particularly 5-HT4 receptors. Cisapride has historically been used in pharmaceutical formulations for gastrointestinal motility disorders.
Cisapride is chemically identified as (±)-cis-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide. Its molecular formula is C₂₃H₂₉ClFN₃O₄, with a molecular weight of approximately 465.95 g/mol.
| Parameter | Details |
|---|---|
| Product Name | Cisapride |
| Generic Name | Cisapride |
| CAS Number | 81098-60-4 |
| Molecular Formula | C₂₃H₂₉ClFN₃O₄ |
| Molecular Weight | 465.95 g/mol |
| Chemical Class | Benzamide derivative |
| Therapeutic Class | Gastroprokinetic agent |
| Physical Form | Solid / crystalline powder |
| Stereochemistry | Cis configuration |
| Category | Active Pharmaceutical Ingredient |
Cisapride has been used as a gastrointestinal prokinetic agent for disorders associated with impaired gastrointestinal motility. Its pharmacological activity is primarily associated with serotonin receptor modulation and enhancement of gastrointestinal motility.
Cisapride API is subject to appropriate pharmaceutical quality controls, including identity, assay, related substances, residual solvents, water content and other applicable quality attributes according to the approved specification for the material.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.1% |
| pH (1% Solution) | 2.0 – 4.0 |
| Water Content | NMT 0.5% |
| Melting Point | Approximately 124–127°C |