Chlorphenesin is a synthetic antimicrobial and preservative ingredient used in suitable cosmetic and personal care formulations. Chemically known as 3-(4-Chlorophenoxy)-1,2-propanediol, Chlorphenesin belongs to the chlorophenoxy-propanediol class and is identified by CAS Number 104-29-0 and EC Number 203-192-6.
As a Chlorphenesin cosmetic ingredient, it is primarily relevant to formulation systems where protection against microbial growth is required. COSMILE Europe identifies CHLORPHENESIN with the cosmetic functions ANTIMICROBIAL and PRESERVATIVE.
For companies searching for a Chlorphenesin Cosmetic Ingredient Manufacturer in India, Chlorphenesin Cosmetic Grade, Chlorphenesin Preservative, Chlorphenesin Antimicrobial Ingredient, or Chlorphenesin Bulk Ingredient, the chemical identity, purity, physical characteristics, documentation and regulatory requirements should be evaluated before formulation use.
Chlorphenesin is a synthetic organic compound containing a chlorophenoxy group and a propane-1,2-diol structure. Its chemical description is 3-(4-Chlorophenoxy)-1,2-propanediol.
The ingredient is identified as:
The molecular formula and molecular weight are also reported by Sigma-Aldrich for its Chlorphenesin analytical standard.
Preservation is an important part of cosmetic product development, particularly for formulations containing water or other components that can support microbial growth.
Chlorphenesin cosmetic ingredient is used for its antimicrobial and preservative functions. COSMILE Europe explains that preservatives help protect cosmetic products from microbial spoilage and are particularly relevant to water-containing formulations.
In practical formulation development, Chlorphenesin may be incorporated into a broader preservation system depending on the formulation composition and target product.
The performance of a preservative system can be influenced by:
The final product should therefore be evaluated through appropriate stability and microbiological testing.
Chlorphenesin can be evaluated for suitable cosmetic and personal-care applications where antimicrobial or preservative functionality is required.
Potential formulation areas include:
The actual application and concentration must be determined according to the finished formulation, intended use and applicable regulations.
Chlorphenesin is relevant to skin-care formulations primarily because of its antimicrobial and preservative functions.
In creams, lotions, gels and other water-containing cosmetic systems, formulators need to control microbial contamination while maintaining product stability and consumer acceptability.
When developing a Chlorphenesin-containing formulation, manufacturers may evaluate:
The suitability of the ingredient should be confirmed in the complete finished formulation rather than from the raw material alone.
The use of Chlorphenesin personal care ingredient is particularly relevant to manufacturers developing formulations where antimicrobial protection forms part of the product's preservation strategy.
A complete formulation assessment should consider interactions between Chlorphenesin and other ingredients. This is important because preservatives can behave differently depending on the formulation environment.
Manufacturers should evaluate:
Raw Material Quality → Formulation Compatibility → Concentration → pH → Preservation System → Stability → Microbiological Testing
This approach helps establish whether the ingredient is suitable for the intended cosmetic formulation.
Chlorphenesin is a synthetic chlorophenoxy-propanediol compound with a molecular weight of 202.63 g/mol. Sigma-Aldrich's analytical-standard listing gives the formula C₉H₁₁ClO₃, CAS 104-29-0 and assay ≥98.0% by GC for that particular analytical standard.
The ≥98.0% GC value is supplier/product-specific and should not automatically be used as the specification for SDP's cosmetic-grade material.
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For professional procurement of Chlorphenesin cosmetic ingredient, manufacturers may evaluate:
The exact limits should correspond to the actual grade and approved Certificate of Analysis.
Where a supplier-specific analytical standard gives ≥98.0% GC, that value should be identified as a GC assay rather than converted into an HPLC specification.
For companies searching for a Chlorphenesin Manufacturer in India, product consistency, technical documentation and specification control are important factors during raw-material qualification.
Swapnroop Drugs & Pharmaceuticals provides technical ingredient information for cosmetic manufacturers, personal-care companies, formulation teams, R&D professionals and bulk ingredient buyers.
Chlorphenesin can be evaluated for bulk cosmetic ingredient requirements according to the required grade, specification, packaging and intended application.
Bulk procurement of Chlorphenesin cosmetic ingredient may require evaluation of:
These parameters help manufacturers establish a suitable raw-material qualification process.
Chlorphenesin is specifically listed as a permitted cosmetic preservative in the European Union.
The current ECHA presentation of Annex V of the EU Cosmetics Regulation identifies Chlorphenesin, CAS 104-29-0, under Reference Number 50, with a maximum threshold of 0.3%. The current ECHA page states that the Annex V list was updated by Regulation (EU) 2026/78.
The corresponding chemical name is 3-(p-Chlorophenoxy)-propane-1,2-diol, and the INCI name is Chlorphenesin.
Therefore, the 0.3% figure is a finished cosmetic product regulatory limit, not a raw-material assay.
The raw material and finished-product concentration are completely different specification concepts.
Cosmetic manufacturers should verify the current regulations applicable to the finished product and destination market before commercialization.
A cosmetic preservation system may contain one or more preservative substances selected according to the formulation requirements.
Chlorphenesin can be evaluated alongside other suitable preservative ingredients based on:
COSMILE Europe notes that cosmetic products can contain multiple preservatives and that preservation systems may work against different bacteria, yeasts and moulds.
Preservative efficacy should always be demonstrated in the finished formulation through appropriate testing.
Chlorphenesin is positioned for manufacturers evaluating antimicrobial and preservative ingredients for suitable cosmetic applications.
CAS number, INCI name, chemical identity and relevant technical parameters support professional raw-material evaluation.
Chlorphenesin can be evaluated for B2B and bulk ingredient requirements according to the required grade and specification.
Appropriate technical documentation and batch information can support raw-material qualification.
Information covering Chlorphenesin's antimicrobial and preservative functions helps formulation and R&D teams evaluate its potential use.
Chlorphenesin is a defined antimicrobial and preservative cosmetic ingredient with CAS 104-29-0, molecular formula C₉H₁₁ClO₃, and molecular weight 202.63 g/mol. Its cosmetic functions are recognized by COSMILE Europe, while EU Annex V establishes conditions for its use as a preservative.
| Parameter | Specification |
|---|---|
| Appearance | White or colourless crystals / white powder |
| Assay (HPLC) | ≥98.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| Water Content | NMT 1.0% |