Swapnroop offers Carbomer 974LP as a pharmaceutical excipient for formulation applications requiring high viscosity, rheology modification, suspension stabilization, bioadhesion and controlled-release functionality.
Carbomer 974P-type polymers are high-molecular-weight, crosslinked polyacrylic acid polymers used as functional pharmaceutical excipients. Pharmaceutical carbomers are valued for their ability to modify viscosity and rheology and are used in liquid, semisolid and oral pharmaceutical formulations.
Carbomer 974P NF is classified as a carbomer homopolymer Type B. Lubrizol's pharmaceutical specification identifies Carbopol 974P NF as meeting relevant USP/NF, Ph. Eur., IP and ChP requirements and describes it as a white, fluffy powder with a slightly acetic odor.
The material provides high viscosity at relatively low concentration and can be used for formulation systems where controlled rheology, suspension properties, gel formation or adhesion are required.
Carbomer 974LP/974P is a crosslinked polyacrylic acid polymer. The commonly used CAS number associated with Carbomer 974P is 9003-01-4. Lubrizol's pharmaceutical polymer documentation also identifies 9003-01-4 as the alternative CAS associated with Carbomer 974P, while regulatory databases may use 9007-20-9 for the generic term carboxypolymethylene.
Chemical Formula: (C₃H₄O₂)n
INCI Name: Carbomer
Physical Form: White, fluffy powder
Excipient Type: Carbomer / crosslinked polyacrylic acid polymer
Carbomer 974P-type pharmaceutical polymers are used in a range of pharmaceutical formulation applications, including:
Lubrizol specifically lists 974P NF for oral pharmaceutical applications including suspensions, bioadhesive formulations, roller compaction and wet granulation, and direct-compression applications; it also identifies applications in topical gels, lotions and creams.
Carbomer 974LP can provide efficient thickening and rheology modification at relatively low use levels. Its crosslinked polymer structure allows it to develop substantial viscosity after dispersion and neutralization.
Depending on the formulation, carbomer polymers can contribute to:
Different carbomer grades have different viscosity and performance characteristics, so formulation substitution should always be evaluated against the relevant product specification and regulatory requirements.
Carbomer 974P NF specifications include identification testing, carboxylic-acid content, viscosity, loss on drying, residual solvent and residue-on-ignition testing.
The Lubrizol specification for Carbopol 974P NF lists:
Swapnroop provides pharmaceutical excipient materials for formulation development and manufacturing requirements. Carbomer 974LP can be positioned for customers looking for high-viscosity carbomer excipients for pharmaceutical gels, suspensions, topical formulations, oral dosage forms and controlled-release applications.
The material can be supplied according to the applicable grade, customer specification and documentation requirements.
Carbomer should be protected from moisture and contamination and stored in tightly closed packaging under suitable cool and dry conditions according to the applicable product specification and Safety Data Sheet.
Because carbomer is a fine polymeric powder, appropriate handling procedures should be followed during dispensing and formulation.
Depending on customer and regulatory requirements, documentation may include:
Carbomer 974LP is suitable for pharmaceutical formulations requiring high viscosity, rheology modification, suspension stabilization, bioadhesion and controlled-release functionality.
Swapnroop supports pharmaceutical customers with specification-focused pharmaceutical excipient supply and relevant technical documentation for formulation and manufacturing requirements.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 2.5% |
| Water Content | NMT 2.0% |