Swapnroop Drugs & Pharmaceuticals offers Bufexamac API for pharmaceutical manufacturing, formulation development and research applications. Bufexamac is a hydroxamic acid derivative with anti-inflammatory, analgesic and antipyretic properties.
Bufexamac is chemically identified as 2-(4-butoxyphenyl)-N-hydroxyacetamide and has the molecular formula C12H17NO3 with a molecular weight of 223.27 g/mol. Its CAS number is 2438-72-4.
Bufexamac is a synthetic non-steroidal anti-inflammatory compound belonging to the hydroxamic acid class. It has been described as having anti-inflammatory, analgesic and antipyretic activity and has historically been used in topical, oral and rectal pharmaceutical preparations.
Bufexamac is listed under CAS 2438-72-4 and FDA UNII 4T3C38J78L. Its PubChem CID is 2466.
Product Name: Bufexamac
Synonyms: Bufexamic acid; 2-(4-Butoxyphenyl)acetohydroxamic acid
CAS Number: 2438-72-4
Molecular Formula: C12H17NO3
Molecular Weight: 223.27 g/mol
IUPAC Name: 2-(4-butoxyphenyl)-N-hydroxyacetamide
Chemical Class: Hydroxamic acid derivative
Therapeutic Category: Non-steroidal anti-inflammatory agent
Bufexamac has anti-inflammatory, analgesic and antipyretic properties. Historical pharmaceutical applications include topical, oral and rectal administration.
Bufexamac occurs as a white to pale yellowish-white crystalline powder according to the Japanese official monograph. It is freely soluble in N,N-dimethylformamide, sparingly soluble in methanol and ethanol, and practically insoluble in water and diethyl ether.
TCI describes Bufexamac as a white to almost-white powder to crystal and reports a melting point of approximately 164 °C with decomposition.
Appearance: White to pale yellowish-white crystalline powder
Identification: Positive identification by official chemical and spectroscopic tests
Assay: Not less than 98.0% on the dried basis
Purity (HPLC): Minimum 98.0 area%
Loss on Drying: Not more than 2.0% according to the applicable official monograph
Residue on Ignition: Not more than 0.5%
Heavy Metals: Not more than 20 ppm
pH (1% Solution): Not specified as a universal official release parameter
Individual Impurity: Not specified in the cited official monograph
Total Impurities: Not specified as a universal official release parameter
Water Content: Not more than 2.0%
Specific Rotation: Not applicable; Bufexamac has no defined stereocentre
Melting Point: Approximately 162–164 °C, with decomposition
Solubility: Freely soluble in N,N-dimethylformamide; sparingly soluble in methanol and ethanol; practically insoluble in water and diethyl ether
Bufexamac API can be supplied in suitable pharmaceutical-grade packaging according to customer requirements, product quantity and applicable handling requirements.
Applicable documentation may include Certificate of Analysis (CoA), product specification, safety documentation and other quality documents according to product grade and customer requirements.
Store Bufexamac in a tightly closed container in a cool, dry and well-ventilated place, protected from excessive moisture and direct exposure to unsuitable environmental conditions. Follow the applicable product specification and stability requirements.
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical customers with API sourcing and supply requirements. Contact Swapnroop Drugs & Pharmaceuticals for Bufexamac availability, specifications, documentation, packaging and commercial supply information.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Complies with official identification tests |
| Assay (HPLC) | ≥98.0% |
| Loss on Drying | ≤2.0% |
| Residue on Ignition | ≤0.5% |
| Heavy Metals | ≤20 ppm |