Swapnroop Drugs & Pharmaceuticals offers Buclizine API for pharmaceutical manufacturing, formulation development and research applications. Buclizine is a piperazine-derived antihistamine with antiemetic and antivertigo properties.
Buclizine is chemically identified as 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine. It has the molecular formula C28H33ClN2 and a molecular weight of approximately 433.0 g/mol. The CAS number is 82-95-1. PubChem and NIST independently identify these chemical properties.
Buclizine belongs to the diphenylmethylpiperazine family of antihistamines. It acts primarily as a histamine H1 receptor antagonist and also has anticholinergic activity.
Buclizine has been used for the prevention and treatment of nausea, vomiting and dizziness associated with motion sickness and vertigo. It has also been described as an antiemetic and antivertigo pharmaceutical compound.
Product Name: Buclizine
Chemical Name: 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
CAS Number: 82-95-1
Molecular Formula: C28H33ClN2
Molecular Weight: 433.0 g/mol
InChIKey: MOYGZHXDRJNJEP-UHFFFAOYSA-N
Chemical Class: Piperazine derivative
Therapeutic Category: Antihistamine / Antiemetic / Antivertigo
ATC Classification: R06AE01
Buclizine has antihistamine, antiemetic and antivertigo properties. It has been used in pharmaceutical preparations for nausea, vomiting, motion sickness and vertigo.
Buclizine is a synthetic organic compound with the molecular formula C28H33ClN2. PubChem reports a calculated molecular weight of 433.0 g/mol and XLogP3-AA of approximately 7.1. NIST independently reports a molecular weight of 433.028 g/mol.
Buclizine is reported to have low water solubility. PubChem lists an experimental solubility of approximately 2.46 × 10−4 g/L.
Appearance: Solid / crystalline pharmaceutical material
Identification: HPLC / GC / IR according to applicable specification
Assay (HPLC): Product-specific pharmaceutical specification
Loss on Drying: Product-specific specification
Residue on Ignition: Product-specific specification
Heavy Metals: Complies with applicable elemental impurity requirements
pH (1% Solution): Not applicable as a universal specification for the free-base compound
Individual Impurity: Product-specific specification
Total Impurities: Product-specific specification
Water Content: Product-specific specification
Specific Rotation: Not applicable for the racemic material
Melting Point: Product-specific reference specification
Solubility: Very slightly soluble in water; approximately 2.46 × 10−4 g/L reported experimentally
Buclizine API can be supplied in suitable pharmaceutical-grade packaging according to customer requirements, quantity, product grade and applicable pharmaceutical handling requirements.
Applicable documentation may include Certificate of Analysis (CoA), product specification, safety documentation and other quality documents according to product grade and customer requirements.
Store Buclizine in a tightly closed container under suitable pharmaceutical storage conditions, protected from excessive moisture, heat and unsuitable environmental exposure. Refer to the applicable product specification for exact storage requirements.
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical customers with API sourcing and supply requirements. Contact Swapnroop Drugs & Pharmaceuticals for Buclizine availability, specifications, documentation, packaging and commercial supply information.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | HPLC / GC / IR |
| Assay (HPLC) | Actual % limit |
| Loss on Drying | Actual % limit |
| Residue on Ignition | Actual % limit |