Swapnroop Drugs & Pharmaceuticals offers Brimonidine (UK14304) API for pharmaceutical and research applications. Brimonidine is a selective alpha-2 adrenergic receptor agonist and is chemically identified as 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine.
Brimonidine, also known as UK 14,304, UK14304 and AGN190342, is an imidazoline-derived alpha-2 adrenergic receptor agonist. It is used in ophthalmic and topical pharmaceutical applications.
Brimonidine is used in ophthalmic formulations for reducing elevated intraocular pressure and is also used in topical dermatological formulations. Its pharmacological activity is primarily associated with alpha-2 adrenergic receptor agonism.
Brimonidine is supplied as a solid powder or crystalline material. Published supplier specifications describe its appearance as yellow to light-yellow/amber powder or crystals. Reported melting-point values vary between sources and product specifications, so the exact value should be controlled against the relevant material specification.
Brimonidine can be characterized using IR spectroscopy, HPLC and non-aqueous titration. Commercial analytical specifications report HPLC purity values of at least 97.5% or 98.0%, depending on the supplier and grade.
For research-grade Brimonidine, supplier information recommends storage in a cool, dark and tightly closed environment. TCI specifies a cool and dark place below 15°C, while other research suppliers specify refrigerated storage. Follow the storage condition associated with the specific batch and supplier documentation.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR |
| Assay (HPLC) | NLT 98.0% |
| Residue on Ignition | NMT 0.3% |
| Melting Point | 245 – 249°C |
| Solubility | Insoluble in water; soluble in DMSO |