Swapnroop Drugs & Pharmaceuticals offers Brimonidine API for pharmaceutical manufacturing and research applications. Brimonidine is an alpha-2 adrenergic receptor agonist used primarily in ophthalmic preparations and is also used in topical dermatological formulations.
Brimonidine is an imidazoline derivative and selective alpha-2 adrenergic receptor agonist. In ophthalmic preparations, it reduces intraocular pressure primarily by decreasing aqueous humor production and increasing uveoscleral outflow.
Brimonidine is widely used as an active pharmaceutical ingredient in ophthalmic formulations for the management of elevated intraocular pressure associated with glaucoma and ocular hypertension. It is also used in topical formulations for the treatment of persistent facial erythema associated with rosacea.
Brimonidine is a white to slightly yellow crystalline powder. It is a lipophilic compound with limited solubility in water and is soluble in certain organic solvents.
Brimonidine can be characterized using analytical techniques including infrared spectroscopy, HPLC and other validated pharmaceutical analytical methods. Quality evaluation may include identification, assay, related substances, loss on drying, residue on ignition, water content and other applicable physicochemical tests.
Brimonidine API should be stored in a tightly closed container in a cool, dry environment and protected from excessive moisture, heat and light.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR / HPLC |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| pH (1% Solution) | NMT 0.5% |
| Melting Point | 207 – 210°C |
| Solubility | Slightly soluble in water; soluble in methanol |