Betaxolol Hydrochloride is a cardioselective beta-adrenergic receptor blocking agent and pharmaceutical active ingredient. It is used in pharmaceutical formulations, particularly in ophthalmic preparations for the management of elevated intraocular pressure.
Betaxolol selectively blocks β₁-adrenergic receptors and reduces sympathetic stimulation. In ophthalmic formulations, it lowers intraocular pressure primarily by reducing aqueous humor production.
USP identifies Betaxolol Hydrochloride as the racemic hydrochloride of betaxolol.
Betaxolol Hydrochloride is used in formulations for:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms — IR and Chloride identification |
| Assay (HPLC) | 98.0% – 102.0% on dried basis |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| pH (1% Solution) | 4.5 – 6.5 |
| Individual Impurity | NMT 0.3% |