Besifloxacin Hydrochloride is a fourth-generation fluoroquinolone antibacterial active pharmaceutical ingredient. It has broad-spectrum antibacterial activity and acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, repair and cell division.
Besifloxacin is primarily used in ophthalmic antibacterial formulations, particularly for the treatment of bacterial conjunctivitis.
PubChem confirms the molecular formula C₁₉H₂₂Cl₂FN₃O₃, molecular weight 430.3 g/mol, and CAS 405165-61-9.
Besifloxacin Hydrochloride is used for:
Besifloxacin inhibits DNA gyrase and topoisomerase IV in susceptible bacteria, interfering with DNA replication, transcription, repair and bacterial cell division.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | Conforms by IR / chromatographic identification |
| Assay (HPLC) | NLT 98.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| pH (1% Solution) | 3.0 – 5.0 |