Atropine Sulfate is a pharmaceutical active ingredient belonging to the class of antimuscarinic agents. It is the sulfate salt of atropine, a naturally occurring tropane alkaloid derived from plants of the Solanaceae family.
Atropine acts primarily by competitively blocking muscarinic acetylcholine receptors, producing anticholinergic effects in various organs and tissues.
Atropine sulfate is commonly supplied as the monohydrate salt. The molecular weight of the monohydrate form is approximately 694.84 g/mol, so the exact hydrate form should be confirmed against your supplier specification before publication.
Atropine is used in pharmaceutical formulations for applications including:
Atropine competitively inhibits the actions of acetylcholine at muscarinic receptors, thereby reducing parasympathetic activity.
Atropine Sulfate API should be manufactured, tested and released according to the applicable pharmacopoeial and approved product specifications. Quality controls may include identification, assay, related substances, water content, residue on ignition, elemental impurities and other applicable tests.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | Conforms to identification tests for Atropine Sulfate |
| Assay (HPLC) | As per applicable pharmacopoeial/approved product specification |
| Individual Impurity | As per applicable related-substances specification |
| Water Content | As per approved specification / hydrate form |
| Specific Rotation | As per applicable pharmacopoeial specification |
| Melting Point | As per approved specification |
| Solubility | Freely soluble in water; soluble in alcohol |