Acetyl Tetrapeptide-5 is a synthetic tetrapeptide cosmetic ingredient consisting of an acetylated four-amino-acid peptide sequence. It is commonly associated with the trade name Eyeseryl and is particularly used in cosmetic formulations developed for the eye contour area, including products focused on the appearance of puffiness and tired-looking skin.
The chemical name is N-acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine, with the peptide sequence Ac-β-Ala-His-Ser-His-OH. Its CAS number is 820959-17-9, molecular formula is C20H28N8O7, and molecular weight is approximately 492.5 g/mol.
Acetyl Tetrapeptide-5 is listed as a humectant in European cosmetic-ingredient information. Commercial cosmetic references also describe its use in moisturizing, soothing, smoothing and refreshing formulations.
It can be incorporated into suitable eye serums, eye creams, facial serums, gels, moisturizers and other leave-on cosmetic formulations.
Acetyl Tetrapeptide-5 is an acetylated tetrapeptide composed of beta-alanine, histidine, serine and histidine.
Key characteristics include:
CAS No.: 820959-17-9
INCI Name: Acetyl Tetrapeptide-5
Common Name: Eyeseryl
Chemical Name: N-acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine
Peptide Sequence: Ac-β-Ala-His-Ser-His-OH
Molecular Formula: C20H28N8O7
Molecular Weight: approximately 492.5 g/mol.
Ac-β-Ala-His-Ser-His-OH
The four residues are:
The complete chemical identity is N-acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine.
Acetyl Tetrapeptide-5 is particularly associated with cosmetic formulations for the eye contour area.
Potential applications include:
Commercial cosmetic references describe its use in formulations targeting the appearance of under-eye puffiness and dark circles, while the official European cosmetic-ingredient information classifies the ingredient as a humectant.
Acetyl Tetrapeptide-5 can be incorporated into suitable water-based and leave-on serum systems.
Potential applications include:
Potential cream applications include:
The ingredient can also be considered for:
Important factors include:
Acetyl Tetrapeptide-5 is reported as water soluble in commercial cosmetic references. Cayman Chemical reports solubility of 10 mg/mL in PBS at pH 7.2 for its research-grade material.
A commercial cosmetic-ingredient reference reports a technical pH range of approximately 4–7. The final formulation pH should be selected according to the specific commercial grade and supplier documentation.
Avoid unnecessary exposure to high temperatures. The actual incorporation procedure should follow the supplier's TDS and stability recommendations.
Storage is grade-dependent. One commercial technical sheet recommends −20°C for 24 months or 2–8°C for 12 months.
For the SDP CMS, use the actual commercial-grade SDS/TDS for the final storage specification.
Acetyl Tetrapeptide-5 can be considered for:
Acetyl Tetrapeptide-5 is a synthetic acetylated tetrapeptide cosmetic ingredient commonly associated with Eyeseryl.
The CAS number is 820959-17-9.
The INCI name is Acetyl Tetrapeptide-5.
Eyeseryl is a commonly used trade name associated with Acetyl Tetrapeptide-5.
The sequence is Ac-β-Ala-His-Ser-His-OH.
It is primarily used as a humectant cosmetic ingredient, with commercial formulations commonly targeting the eye contour and moisturizing applications.
Yes. It is commonly incorporated into eye creams and other eye-contour cosmetic formulations.
Yes. It can be incorporated into suitable eye and facial serum formulations.
Yes, commercial references describe it as water soluble.
The molecular formula is C20H28N8O7.
The molecular weight is approximately 492.5 g/mol.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white powder |